講座題目:Robust joint models for complex longitudinal and survival data
主 講 人:吳浪
講座時間:2024年6月6日(周四)14:00-15:30
講座地點:6號學院樓500會議室
主辦單位:新葡萄8883官網AMG、浙江省2011協同創新中心(數據科學與大數據分析協同創新中心)
摘 要:
In a survival model with a time-dependent covariate, the covariate may be left censored due to a lower detection limit and its observed values may contain outliers. Motivated from an HIV vaccine study, we propose a robust method for joint models of longitudinal and survival data, where the outliers in longitudinal data are addressed using a multivariate t-distribution for b-outliers and using an M-estimator for e-outliers. We also propose a computationally efficient method for approximate likelihood inference. The proposed method is evaluated by simulation studies. Based on the proposed models and method,we analyze the HIV vaccine data and find a strong association between longitudinal biomarkers and the risk of HIV infection.
主講人簡介:
吳浪,華盛頓大學統計學博士,哈佛大學生物統計學博士后,加拿大不列顛哥侖比亞大學(UBC)統計系終身教授。吳浪教授的研究主要來自對健康科學數據集的分析,例如艾滋病/艾滋病病毒研究、癌癥研究或疫苗研究。主要關注點是當存在缺失值、刪失值、測量誤差和異常值的情況下對縱向數據進行分析。吳浪教授研究成果豐碩,共出版專著2部,發表60余篇學術論文,主持加拿大國家自然科學基金項目多項。
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